Comparison of the Effect of Clinical Practice Guide of Budesonide (Pulmicort) and Standard Method in the Management of Asthma Attack

Abstract

Background: Asthma is the most common chronic respiratory tract disorder, and so far, numerous methods for controlling asthma attacks have been presented. The aim of this study was to compare the effect of the use of the budesonide (Pulmicort) clinical guide with the current standard treatment of acute asthma attacks. Methods: In this randomized clinical trial study, 90 patients with history or presentation of acute asthma attack were selected, and randomly divided into two groups of 45. The intervention group received 0.5 mg inhaled budesonide for one time plus standard protocol, and the control group received standard protocol only. The standard protocol consisted of 5 mg of salbutamol (4-10 puff) in 3 doses (with an interval of 20 minutes) via nebulizer, 0.5 mg of ipratropium in 3 doses (with an interval of 20 minutes) via inhalation, and 50 mg of prednisolone orally. Then, the peak expiratory flow rate (PEFR), forced expiratory volume in one second (FEV1), and hemodynamic parameters at 20th, 40th, and 60th minutes were measured and compared between the two groups. Findings: In intervention and control groups, the mean PEFR was 180.04 ± 8.51 and 175.17 ± 6.25 liter/minute (P = 0.003), 225.88 ± 13.34 and 219.68 ± 13.21 liter/minute (P = 0.029), and 424.02 ± 86.8 and 361.64 ± 75.44 liter/minute (P < 0.001) at 20th, 40th, and 60th minutes, respectively. Conclusion: It seems that budesonide (Pulmicort) protocol appears to be effective in accelerating the treatment process in acute asthma attacks.

Keywords

• asthma
• pulmicort
• clinical practice guideline