Nature Communications (Nov 2021)
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
- Dominik Laubscher,
- Berkley E. Gryder,
- Benjamin D. Sunkel,
- Thorkell Andresson,
- Marco Wachtel,
- Sudipto Das,
- Bernd Roschitzki,
- Witold Wolski,
- Xiaoli S. Wu,
- Hsien-Chao Chou,
- Young K. Song,
- Chaoyu Wang,
- Jun S. Wei,
- Meng Wang,
- Xinyu Wen,
- Quy Ai Ngo,
- Joana G. Marques,
- Christopher R. Vakoc,
- Beat W. Schäfer,
- Benjamin Z. Stanton,
- Javed Khan
Affiliations
- Dominik Laubscher
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Berkley E. Gryder
- Genetics Branch, NCI, NIH
- Benjamin D. Sunkel
- Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases
- Thorkell Andresson
- Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
- Marco Wachtel
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Sudipto Das
- Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
- Bernd Roschitzki
- Functional Genomics Center, University of Zurich/ETH Zurich
- Witold Wolski
- Functional Genomics Center, University of Zurich/ETH Zurich
- Xiaoli S. Wu
- Cold Spring Harbor Laboratory
- Hsien-Chao Chou
- Genetics Branch, NCI, NIH
- Young K. Song
- Genetics Branch, NCI, NIH
- Chaoyu Wang
- Genetics Branch, NCI, NIH
- Jun S. Wei
- Genetics Branch, NCI, NIH
- Meng Wang
- Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases
- Xinyu Wen
- Genetics Branch, NCI, NIH
- Quy Ai Ngo
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Joana G. Marques
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Christopher R. Vakoc
- Cold Spring Harbor Laboratory
- Beat W. Schäfer
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Benjamin Z. Stanton
- Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases
- Javed Khan
- Genetics Branch, NCI, NIH
- DOI
- https://doi.org/10.1038/s41467-021-27176-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is overexpressed and acts largely independently of the PAX3-FOXO1 chimera on chromatin to result in a myogenic differentiation blockade in this malignancy.
