Stem cell homeostasis regulated by hierarchy and neutral competition

Asahi Nakamuta; Kana Yoshido; Honda Naoki

doi:10.1038/s42003-022-04218-7

Communications Biology (Nov 2022)

Stem cell homeostasis regulated by hierarchy and neutral competition

Asahi Nakamuta,
Kana Yoshido,
Honda Naoki

Affiliations

Asahi Nakamuta: Laboratory of Theoretical Biology, Graduate School of Biostudies, Kyoto University, Yoshidakonoecho, Sakyo
Kana Yoshido: Laboratory of Theoretical Biology, Graduate School of Biostudies, Kyoto University, Yoshidakonoecho, Sakyo
Honda Naoki: Laboratory of Theoretical Biology, Graduate School of Biostudies, Kyoto University, Yoshidakonoecho, Sakyo

DOI: https://doi.org/10.1038/s42003-022-04218-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

A mathematical model of stem cell homeostasis is presented that comprehensively satisfies hierarchy and neutral competition is presented. The model predicts spontaneous generation of clonal bursts, which is consistent with primate hematopoietic data.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal