Nature Communications (May 2018)

Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

  • Jerome J. Lacroix,
  • Wesley M. Botello-Smith,
  • Yun Luo

DOI
https://doi.org/10.1038/s41467-018-04405-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic insights into Piezo-mediated mechanotransduction.