Tobacco, Alcohol and Family History of Cancer as Risk Factors of Oral Squamous Cell Carcinoma: Case-Control Retrospective Study

Gianluca Tenore; Alessandro Nuvoli; Ahmed Mohsen; Andrea Cassoni; Andrea Battisti; Valentina Terenzi; Marco Della Monaca; Ingrid Raponi; Edoardo Brauner; Francesca De Felice; Daniela Musio; Cira Rosaria Tiziana Di Gioia; Daniela Messineo; Silvia Mezi; Stefano Di Carlo; Andrea Botticelli; Valentino Valentini; Paolo Marchetti; Vincenzo Tombolini; Marco De Vincentiis; Antonella Polimeni; Umberto Romeo

doi:10.3390/app10113896

Applied Sciences (Jun 2020)

Tobacco, Alcohol and Family History of Cancer as Risk Factors of Oral Squamous Cell Carcinoma: Case-Control Retrospective Study

Gianluca Tenore,
Alessandro Nuvoli,
Ahmed Mohsen,
Andrea Cassoni,
Andrea Battisti,
Valentina Terenzi,
Marco Della Monaca,
Ingrid Raponi,
Edoardo Brauner,
Francesca De Felice,
Daniela Musio,
Cira Rosaria Tiziana Di Gioia,
Daniela Messineo,
Silvia Mezi,
Stefano Di Carlo,
Andrea Botticelli,
Valentino Valentini,
Paolo Marchetti,
Vincenzo Tombolini,
Marco De Vincentiis,
Antonella Polimeni,
Umberto Romeo

Affiliations

Gianluca Tenore: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Alessandro Nuvoli: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Ahmed Mohsen: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Andrea Cassoni: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Andrea Battisti: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Valentina Terenzi: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Marco Della Monaca: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Ingrid Raponi: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Edoardo Brauner: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Francesca De Felice: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Daniela Musio: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Cira Rosaria Tiziana Di Gioia: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Daniela Messineo: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Silvia Mezi: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Stefano Di Carlo: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Andrea Botticelli: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Valentino Valentini: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Paolo Marchetti: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Vincenzo Tombolini: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Marco De Vincentiis: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Antonella Polimeni: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy
Umberto Romeo: Head and Neck Tumor Board, Polyclinic Umberto I, Sapienza University of Rome, 00161 Rome, Italy

DOI: https://doi.org/10.3390/app10113896
Journal volume & issue: Vol. 10, no. 11
p. 3896

Abstract

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The aim of the study is to observe retrospectively the correlation between Oral Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG) consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and FHC; including the General Family History of Cancer (GFHC) and Family History of Head and Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco consumption was associated with an OR of 1.035 (95% CI 1.001–1.070) and a statistical significance (p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR was 1.035 (95% CI 1.010–1.061). The GFHC was associated with a marginal risk of OSCC with an OR of 1.095 (95% CI 0.953–1.259), without significance (p = 0.199). The FHHNC showed a notable risk increase with an OR of 1.871 (95% CI 0.902–3.882), without significance (p = 0.092). Alcohol and tobacco may be associated with an increase in the risk of OSCC.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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