Frontiers in Immunology (Mar 2024)
Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection
- Emilie Goguet,
- Emilie Goguet,
- Cara H. Olsen,
- William A. Meyer,
- Sara Ansari,
- John H. Powers,
- Tonia L. Conner,
- Si’Ana A. Coggins,
- Si’Ana A. Coggins,
- Wei Wang,
- Richard Wang,
- Luca Illinik,
- Luca Illinik,
- Margaret Sanchez Edwards,
- Margaret Sanchez Edwards,
- Belinda M. Jackson-Thompson,
- Belinda M. Jackson-Thompson,
- Monique Hollis-Perry,
- Gregory Wang,
- Gregory Wang,
- Yolanda Alcorta,
- Yolanda Alcorta,
- Mimi A. Wong,
- Mimi A. Wong,
- David Saunders,
- Roshila Mohammed,
- Roshila Mohammed,
- Bolatito Balogun,
- Bolatito Balogun,
- Priscilla Kobi,
- Priscilla Kobi,
- Lakeesha Kosh,
- Lakeesha Kosh,
- Kimberly Bishop-Lilly,
- Regina Z. Cer,
- Catherine E. Arnold,
- Catherine E. Arnold,
- Logan J. Voegtly,
- Logan J. Voegtly,
- Maren Fitzpatrick,
- Maren Fitzpatrick,
- Andrea E. Luquette,
- Andrea E. Luquette,
- Francisco Malagon,
- Francisco Malagon,
- Orlando Ortega,
- Orlando Ortega,
- Edward Parmelee,
- Edward Parmelee,
- Julian Davies,
- Julian Davies,
- Alyssa R. Lindrose,
- Alyssa R. Lindrose,
- Hannah Haines-Hull,
- Hannah Haines-Hull,
- Matthew S. Moser,
- Matthew S. Moser,
- Emily C. Samuels,
- Emily C. Samuels,
- Marana S. Rekedal,
- Marana S. Rekedal,
- Elizabeth K. Graydon,
- Elizabeth K. Graydon,
- Allison M. W. Malloy,
- David R. Tribble,
- Timothy H. Burgess,
- Wesley Campbell,
- Sara Robinson,
- Christopher C. Broder,
- Robert J. O’Connell,
- Carol D. Weiss,
- Simon Pollett,
- Simon Pollett,
- Eric D. Laing,
- Edward Mitre
Affiliations
- Emilie Goguet
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Emilie Goguet
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Cara H. Olsen
- Department of Preventive Medicine & Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- William A. Meyer
- Quest Diagnostics, Secaucus, NJ, United States
- Sara Ansari
- Quest Diagnostics, Secaucus, NJ, United States
- John H. Powers
- Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States
- Tonia L. Conner
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Si’Ana A. Coggins
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Si’Ana A. Coggins
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Wei Wang
- Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States
- Richard Wang
- Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States
- Luca Illinik
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Luca Illinik
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Margaret Sanchez Edwards
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Margaret Sanchez Edwards
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Belinda M. Jackson-Thompson
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Belinda M. Jackson-Thompson
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Monique Hollis-Perry
- Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States
- Gregory Wang
- Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States
- Gregory Wang
- General Dynamics Information Technology, Falls Church, VA, United States
- Yolanda Alcorta
- Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States
- Yolanda Alcorta
- General Dynamics Information Technology, Falls Church, VA, United States
- Mimi A. Wong
- Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States
- Mimi A. Wong
- General Dynamics Information Technology, Falls Church, VA, United States
- David Saunders
- 0Translational Medicine Unit, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Roshila Mohammed
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Roshila Mohammed
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Bolatito Balogun
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Bolatito Balogun
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Priscilla Kobi
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Priscilla Kobi
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Lakeesha Kosh
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Lakeesha Kosh
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Kimberly Bishop-Lilly
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Regina Z. Cer
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Catherine E. Arnold
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Catherine E. Arnold
- 2Defense Threat Reduction Agency, Fort Belvoir, VA, United States
- Logan J. Voegtly
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Logan J. Voegtly
- 3Leidos, Reston, VA, United States
- Maren Fitzpatrick
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Maren Fitzpatrick
- 3Leidos, Reston, VA, United States
- Andrea E. Luquette
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Andrea E. Luquette
- 3Leidos, Reston, VA, United States
- Francisco Malagon
- 1Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States
- Francisco Malagon
- 3Leidos, Reston, VA, United States
- Orlando Ortega
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Orlando Ortega
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Edward Parmelee
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Edward Parmelee
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Julian Davies
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Julian Davies
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Alyssa R. Lindrose
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Alyssa R. Lindrose
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Hannah Haines-Hull
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Hannah Haines-Hull
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Matthew S. Moser
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Matthew S. Moser
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Emily C. Samuels
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Emily C. Samuels
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Marana S. Rekedal
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Marana S. Rekedal
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Elizabeth K. Graydon
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Elizabeth K. Graydon
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Allison M. W. Malloy
- 4Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- David R. Tribble
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Timothy H. Burgess
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Wesley Campbell
- 5Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, MD, United States
- Sara Robinson
- 5Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, MD, United States
- Christopher C. Broder
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Robert J. O’Connell
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Carol D. Weiss
- Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States
- Simon Pollett
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States
- Simon Pollett
- Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Eric D. Laing
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- Edward Mitre
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
- DOI
- https://doi.org/10.3389/fimmu.2024.1287504
- Journal volume & issue
-
Vol. 15
Abstract
IntroductionWe sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States.MethodsSerum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires.ResultsSerum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range.DiscussionIn the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.
Keywords
