Nature Communications (Mar 2018)

ARMMs as a versatile platform for intracellular delivery of macromolecules

  • Qiyu Wang,
  • Jiujiu Yu,
  • Tatenda Kadungure,
  • Joseph Beyene,
  • Hong Zhang,
  • Quan Lu

DOI
https://doi.org/10.1038/s41467-018-03390-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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One of the challenges of biologic drug therapy is delivery into target cells and tissues. Here the authors present ARMMs (arrestin domain containing protein 1 mediated microvesicles) as a versatile platform for packaging and delivery of a myriad of molecules, including p53, RNAs and CRISPR-Cas9.