Фармакокинетика и Фармакодинамика (Jan 2022)

Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats

  • G. B. Kolyvanov,
  • P. O. Bochkov,
  • A. A. Litvin,
  • R. V. Shevchenko,
  • A. L. Podolko,
  • V. P. Zherdev

DOI
https://doi.org/10.37489/2587-7836-2021-2-31-35
Journal volume & issue
Vol. 0, no. 2
pp. 31 – 35

Abstract

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The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates the potential for the development of a dosage form for oral administration

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