Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Abstract

Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.