A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.

Abstract

A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[α-L-rhamnopyranosyl-(1→6)-α-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.

Keywords

• Hypericum japonicum Thunb.
• 4
• 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol
• Antihypoxic activity