Vms1p is a release factor for the ribosome-associated quality control complex

Olga Zurita Rendón; Eric K. Fredrickson; Conor J. Howard; Jonathan Van Vranken; Sarah Fogarty; Neal D. Tolley; Raghav Kalia; Beatriz A. Osuna; Peter S. Shen; Christopher P. Hill; Adam Frost; Jared Rutter

doi:10.1038/s41467-018-04564-3

Nature Communications (Jun 2018)

Vms1p is a release factor for the ribosome-associated quality control complex

Olga Zurita Rendón,
Eric K. Fredrickson,
Conor J. Howard,
Jonathan Van Vranken,
Sarah Fogarty,
Neal D. Tolley,
Raghav Kalia,
Beatriz A. Osuna,
Peter S. Shen,
Christopher P. Hill,
Adam Frost,
Jared Rutter

Affiliations

Olga Zurita Rendón: Howard Hughes Medical Institute
Eric K. Fredrickson: Department of Biochemistry, University of Utah School of Medicine
Conor J. Howard: Department of Biochemistry and Biophysics, University of California, San Francisco
Jonathan Van Vranken: Department of Biochemistry, University of Utah School of Medicine
Sarah Fogarty: Howard Hughes Medical Institute
Neal D. Tolley: Molecular Medicine Program, University of Utah
Raghav Kalia: Department of Biochemistry, University of Utah School of Medicine
Beatriz A. Osuna: Department of Biochemistry and Biophysics, University of California, San Francisco
Peter S. Shen: Department of Biochemistry, University of Utah School of Medicine
Christopher P. Hill: Department of Biochemistry, University of Utah School of Medicine
Adam Frost: Department of Biochemistry, University of Utah School of Medicine
Jared Rutter: Howard Hughes Medical Institute

DOI: https://doi.org/10.1038/s41467-018-04564-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

The ribosome-associated quality control complex (RQC) functions to disassemble stalled ribosomes. Here the authors find that the tRNA hydrolase Vms1 is involved in the release of nascent peptide from stalled ribosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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