Defining the impact of dietary macronutrient balance on PCOS traits

Valentina Rodriguez Paris; Samantha M. Solon-Biet; Alistair M. Senior; Melissa C. Edwards; Reena Desai; Nicodemus Tedla; Madeleine J. Cox; William L. Ledger; Robert B. Gilchrist; Stephen J. Simpson; David J. Handelsman; Kirsty A. Walters

doi:10.1038/s41467-020-19003-5

Nature Communications (Oct 2020)

Defining the impact of dietary macronutrient balance on PCOS traits

Valentina Rodriguez Paris,
Samantha M. Solon-Biet,
Alistair M. Senior,
Melissa C. Edwards,
Reena Desai,
Nicodemus Tedla,
Madeleine J. Cox,
William L. Ledger,
Robert B. Gilchrist,
Stephen J. Simpson,
David J. Handelsman,
Kirsty A. Walters

Affiliations

Valentina Rodriguez Paris: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney
Samantha M. Solon-Biet: Charles Perkins Centre, University of Sydney
Alistair M. Senior: Charles Perkins Centre, University of Sydney
Melissa C. Edwards: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney
Reena Desai: Andrology Laboratory, ANZAC Research Institute, University of Sydney
Nicodemus Tedla: School of Medical Sciences, Department of Pathology, University of New South Wales Sydney
Madeleine J. Cox: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney
William L. Ledger: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney
Robert B. Gilchrist: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney
Stephen J. Simpson: Charles Perkins Centre, University of Sydney
David J. Handelsman: Andrology Laboratory, ANZAC Research Institute, University of Sydney
Kirsty A. Walters: Discipline of Obstetrics and Gynaecology, School of Women’s and Children’s Health, University of New South Wales Sydney

DOI: https://doi.org/10.1038/s41467-020-19003-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Lifestyle interventions are first-line treatment for women with polycystic ovary syndrome (PCOS), but the optimal diet remains undefined. Here the authors identify an optimum dietary macronutrient balance that can rectify PCOS reproductive traits in a mouse model of PCOS, while metabolic features were less sensitive to diet changes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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