Synthesis of bioactive glass 60SiO2-33CaO-4P2O5-3Ag2O and its application in toothpaste

Abstract

This work is related to the synthesis of silver-doped bioactive glass material 60SiO2-33CaO-4P2O5-3Ag2O by the modified sol-gel method based on hydrothermal reaction. Several physical-chemical methods such as TG-DSC, XRD, SEM, and TEM were used to evaluate the synthetic bioglass. TG-DSC shows that the processing temperature to form bioglass from dried gel is at 600 oC. XRD confirms the formation of silver crystalline phase on the amorphous phase of glass. SEM and TEM show the porous structure of the glass material containing nano-sized particles. Experiment with cells showed good biocompatibility of the bioglass material with the fibroblast L929 cell-line. Ag-doped bioglass material was mixed to make toothpaste with excellent antibacterial property. All Staphylococcus aureus and Pseudomonas aeruginosa bacteria were destroyed when exposed to toothpaste containing bioglass.

Keywords

• bioactive glass
• bioactivity
• hydroxyapatite
• silver
• biocompatibility
• antibacterial