Nature Communications (Sep 2019)
Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
- Yusuke Matsuno,
- Yuko Atsumi,
- Atsuhiro Shimizu,
- Kotoe Katayama,
- Haruka Fujimori,
- Mai Hyodo,
- Yusuke Minakawa,
- Yoshimichi Nakatsu,
- Syuzo Kaneko,
- Ryuji Hamamoto,
- Teppei Shimamura,
- Satoru Miyano,
- Teruhisa Tsuzuki,
- Fumio Hanaoka,
- Ken-ichi Yoshioka
Affiliations
- Yusuke Matsuno
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Yuko Atsumi
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Atsuhiro Shimizu
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Kotoe Katayama
- Human Genome Center, Institute of Medical Science, University of Tokyo, Shirokanedai
- Haruka Fujimori
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Mai Hyodo
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Yusuke Minakawa
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- Yoshimichi Nakatsu
- Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Maidashi
- Syuzo Kaneko
- Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, Tsukiji
- Ryuji Hamamoto
- Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, Tsukiji
- Teppei Shimamura
- Division of Systems Biology, Graduate School of Medicine, Nagoya University, Tsurumai-cho
- Satoru Miyano
- Human Genome Center, Institute of Medical Science, University of Tokyo, Shirokanedai
- Teruhisa Tsuzuki
- Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Maidashi
- Fumio Hanaoka
- Faculty of Science, Gakushuin University, Mejiro
- Ken-ichi Yoshioka
- Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tsukiji
- DOI
- https://doi.org/10.1038/s41467-019-11760-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.
