Journal of Clinical Medicine (May 2022)
The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic
- Roberto Licordari,
- Alessandro Sticchi,
- Filippo Mancuso,
- Alessandro Caracciolo,
- Saverio Muscoli,
- Fortunato Iacovelli,
- Rossella Ruggiero,
- Alessandra Scoccia,
- Valeria Cammalleri,
- Marco Pavani,
- Marco Loffi,
- Domenico Scordino,
- Jayme Ferro,
- Andrea Rognoni,
- Andrea Buono,
- Stefano Nava,
- Stefano Albani,
- Iginio Colaiori,
- Filippo Zilio,
- Marco Borghesi,
- Valentina Regazzoni,
- Stefano Benenati,
- Fabio Pescetelli,
- Vincenzo De Marzo,
- Antonia Mannarini,
- Francesco Spione,
- Doronzo Baldassarre,
- Michele De Benedictis,
- Roberto Bonmassari,
- Gian Battista Danzi,
- Mario Galli,
- Alfonso Ielasi,
- Giuseppe Musumeci,
- Fabrizio Tomai,
- Vincenzo Pasceri,
- Italo Porto,
- Giuseppe Patti,
- Gianluca Campo,
- Antonio Colombo,
- Antonio Micari,
- Francesco Giannini,
- Francesco Costa
Affiliations
- Roberto Licordari
- Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, Italy
- Alessandro Sticchi
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Filippo Mancuso
- Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, Italy
- Alessandro Caracciolo
- Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, Italy
- Saverio Muscoli
- Department of Cardiovascular Disease, Tor Vergata University, 00133 Rome, Italy
- Fortunato Iacovelli
- Division of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, Italy
- Rossella Ruggiero
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Alessandra Scoccia
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Valeria Cammalleri
- Department of Cardiovascular Disease, Tor Vergata University, 00133 Rome, Italy
- Marco Pavani
- Department of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, Italy
- Marco Loffi
- Department of Cardiology, Ospedale di Cremona, 26100 Cremona, Italy
- Domenico Scordino
- Division of Cardiology, Aurelia Hospital, 00165 Rome, Italy
- Jayme Ferro
- U.O.S.D. Cardiologia-Laboratorio di Emodinamica, Dipartimento di Emergenza, Rianimazione e Anestesia, ASST Lariana, Ospedale S. Anna, 22100 Como, Italy
- Andrea Rognoni
- Department of Cardiology, Azienda Ospedaliero–Universitaria Maggiore della Carità, 28100 Novara, Italy
- Andrea Buono
- Clinical and Interventional Cardiology Unit, Istituto Clinico Sant’Ambrogio, 20149 Milan, Italy
- Stefano Nava
- Division of Invasive Cardiology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Stefano Albani
- Department of Cardiology, Mauriziano Hospital, 10128 Turin, Italy
- Iginio Colaiori
- Azienda Unità Sanitaria Locale, IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
- Filippo Zilio
- U.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, Italy
- Marco Borghesi
- U.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, Italy
- Valentina Regazzoni
- Department of Cardiology, Ospedale di Cremona, 26100 Cremona, Italy
- Stefano Benenati
- Dipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy
- Fabio Pescetelli
- Dipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy
- Vincenzo De Marzo
- Dipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy
- Antonia Mannarini
- Division of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, Italy
- Francesco Spione
- Division of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, Italy
- Doronzo Baldassarre
- Department of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, Italy
- Michele De Benedictis
- Department of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, Italy
- Roberto Bonmassari
- U.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, Italy
- Gian Battista Danzi
- Department of Cardiology, Ospedale di Cremona, 26100 Cremona, Italy
- Mario Galli
- U.O.S.D. Cardiologia-Laboratorio di Emodinamica, Dipartimento di Emergenza, Rianimazione e Anestesia, ASST Lariana, Ospedale S. Anna, 22100 Como, Italy
- Alfonso Ielasi
- Clinical and Interventional Cardiology Unit, Istituto Clinico Sant’Ambrogio, 20149 Milan, Italy
- Giuseppe Musumeci
- Department of Cardiology, Mauriziano Hospital, 10128 Turin, Italy
- Fabrizio Tomai
- Division of Cardiology, Aurelia Hospital, 00165 Rome, Italy
- Vincenzo Pasceri
- Department of Cardiology, San Filippo Neri Roma, 00135 Rome, Italy
- Italo Porto
- Dipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy
- Giuseppe Patti
- Department of Cardiology, Azienda Ospedaliero–Universitaria Maggiore della Carità, 28100 Novara, Italy
- Gianluca Campo
- Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 30010 Cona, Italy
- Antonio Colombo
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Antonio Micari
- Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, Italy
- Francesco Giannini
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Francesco Costa
- Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, Italy
- DOI
- https://doi.org/10.3390/jcm11102926
- Journal volume & issue
-
Vol. 11,
no. 10
p. 2926
Abstract
Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.
Keywords