ASSOCIATION BETWEEN BLOOD 25-(OH)D3 LEVEL AND ACUTE INFECTIOUS DISEASES IN CHILDREN

Abstract

Objective To investigate the association between blood 25-hydroxyvitamin D3 [25-(OH)D3] level and acute infectious diseases in children. Methods A total of 114 children with acute infectious diseases who were admitted to our hospital from October 2021 to May 2022 were enrolled, and according to the severity of infection, they were divided into common infection group with 71 children and sepsis group with 43 children. At the same time, 71 children with non-infectious diseases who were admitted to Department of Pediatric Surgery in our hospital during the same period of time were enrolled as control group. According to age, each group was further divided into infancy (<1 year), young childhood (1-3 years), preschool (4-6 years), and school-aged (7-14 years) groups, and the serum level of 25-(OH)D3 was compared between different age groups. Results Compared with the common infection group and the control group, the sepsis group had a significantly higher proportion of children with insufficiency or deficiency of serum 25-(OH)D3 (χ2=22.843,P<0.05), but there was no significant difference between the common infection group and the control group (P>0.05). In the common infection group and the control group, preschool and school-aged children had a significantly lower serum level of 25-(OH)D3 than the children in infancy and early childhood (P<0.05), but there was no significant difference between preschool and school-aged children and between the children in infancy and those in early childhood (P>0.05). In the sepsis group, there was no significant difference in serum 25-(OH)D3 level between different age groups (P>0.05). Comparison of children with different ages showed that the sepsis group had a significantly lower serum level of 25-(OH)D3 than the common infection group and the control group (F=7.150-58.410,P<0.05), but there was no significant difference between the common infection group and the control group (P>0.05). Conclusion There is no significant correlation between serum 25-(OH)D3 level and age in children with sepsis. For children with acute infectious diseases, the incidence rate of sepsis tends to increase with the reduction in the serum level of 25-(OH)D3, and therefore, 25-(OH)D3 intervention should be performed for children with acute infectious disease as soon as possible.

Keywords

• calcifediol|infections|sepsis|root cause analysis|child