Advances in Urate Excretion and Urate Transporters in Hyperuricemia

XIN  Jiadong, ZHOU  Jiabao, WU  Zhiyuan, ZHANG  Xuming, GAO  Jiandong

doi:10.12114/j.issn.1007-9572.2022.0747

Zhongguo quanke yixue (May 2023)

Advances in Urate Excretion and Urate Transporters in Hyperuricemia

XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong

Affiliations

XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong: 1. Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine1, Shanghai 200120, China;2. TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China;3. Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 200000, China;4. Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China

DOI: https://doi.org/10.12114/j.issn.1007-9572.2022.0747
Journal volume & issue: Vol. 26, no. 15
pp. 1916 – 1922

Abstract

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Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range. It has been found that three common genes ABCG2, SLC2A9 and SLC22A12 have a great influence on serum uric acid level in human body. Other urate transporter genes, such as SLC16A9, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A11, SLC22A13 and ABCC4 also play a crucial role in the regulation of urate levels. This article reviews the urate transporters mentioned above that have been found to be related to the development of hyperuricemia, including uric acid reabsorption transporter and uric acid secretion transporter in kidney, uric acid transporter in intestine, aiming at providing theoretical and data support for future clinical treatment.

hyperuricemia|uric acid|uric acid transporter|gene expression|review

Published in Zhongguo quanke yixue

ISSN: 1007-9572 (Print)
Publisher: Chinese General Practice Publishing House Co., Ltd
Country of publisher: China
LCC subjects: Medicine
Website: https://www.chinagp.net/EN/1007-9572/home.shtml

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