The aim of this work was to answer the following question: can influential points modify the recommendation of genotypes, based on regression methods, in the presence of genotype × environment (G × E)? Therefore, we compared the parameters of the adaptability and stability of three methodologies based on regression in the presence of influential points. Specifically, were evaluated methods based on simple, non-parametric and quantile (τ = 0.50) regressions. The dataset used in this work corresponds to 18 variety trials of cotton cultivars that were conducted in the 2013–2014 and 2014–2015 crop seasons. The evaluated variable was the cotton fiber yield (kg/ha). Once we noticed that the effect of G × E interaction is significant, the statistical procedures adopted for the adaptability and stability analysis of the genotypes. To verify the presence of a possible influential point, we used the leverage values, studentized residuals (SR), DFBETAS and Cook’s distance. As a result, the influential points can modify the recommendation of genotypes, based on regression methods, in the presence of G × E interaction. The non-parametric and quantile (τ = 0.50) regressions, which are based on median estimators, are less sensitive to the presence of influential points avoiding misleading recommendations of genotypes in terms of adaptability.