Nature Communications (Nov 2022)
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
- Scisung Chung,
- Mi-Sun Kang,
- Dauren S. Alimbetov,
- Gil-Im Mun,
- Na-Oh Yunn,
- Yunjin Kim,
- Byung-Gyu Kim,
- Minwoo Wie,
- Eun A. Lee,
- Jae Sun Ra,
- Jung-Min Oh,
- Donghyun Lee,
- Keondo Lee,
- Jihan Kim,
- Seung Hyun Han,
- Kyong-Tai Kim,
- Wan Kyun Chung,
- Ki Hyun Nam,
- Jaehyun Park,
- ByungHoon Lee,
- Sunghoon Kim,
- Weixing Zhao,
- Sung Ho Ryu,
- Yun-Sil Lee,
- Kyungjae Myung,
- Yunje Cho
Affiliations
- Scisung Chung
- Department of Life Sciences, Pohang University of Science and Technology
- Mi-Sun Kang
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Dauren S. Alimbetov
- Department of Biochemistry and Structural Biology, University of Texas Health San Antonio
- Gil-Im Mun
- Graduate School of Pharmaceutical Sciences, Ewha Womans University
- Na-Oh Yunn
- Postech Biotech Center, Pohang University of Science and Technology
- Yunjin Kim
- Department of Life Sciences, Pohang University of Science and Technology
- Byung-Gyu Kim
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Minwoo Wie
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Eun A. Lee
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Jae Sun Ra
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Jung-Min Oh
- Department of Oral Biochemistry, School of Dentistry, Pusan National University
- Donghyun Lee
- Department of Mechanical Engineering, Pohang University of Science and Technology
- Keondo Lee
- Department of Mechanical Engineering, Pohang University of Science and Technology
- Jihan Kim
- Department of Life Sciences, Pohang University of Science and Technology
- Seung Hyun Han
- Department of Life Sciences, Pohang University of Science and Technology
- Kyong-Tai Kim
- Department of Life Sciences, Pohang University of Science and Technology
- Wan Kyun Chung
- Department of Mechanical Engineering, Pohang University of Science and Technology
- Ki Hyun Nam
- Division of Biotechnology, Korea University
- Jaehyun Park
- Pohang Accelerator Laboratory, Pohang University of Science and Technology
- ByungHoon Lee
- Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)
- Sunghoon Kim
- Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy, Gangnam Severance Hospital, Yonsei University
- Weixing Zhao
- Department of Biochemistry and Structural Biology, University of Texas Health San Antonio
- Sung Ho Ryu
- Department of Life Sciences, Pohang University of Science and Technology
- Yun-Sil Lee
- Graduate School of Pharmaceutical Sciences, Ewha Womans University
- Kyungjae Myung
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Yunje Cho
- Department of Life Sciences, Pohang University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-022-34612-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
