Distribution and Related Influencing Factors of AMH Level in Family-Planning Women of Childbearing Age: A Cross-Sectional Study from Beijing, China

Abstract

Jinwei Song,1,* Songkun Gao,2,* Lixia Zhao,1 Xiaolong Tong1 1Women ‘s Health Department, Xicheng District Maternal and Child Health Care Hospital, Beijing, 100054, People’s Republic of China; 2Gynecologic Oncology Department,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinwei Song; Xiaolong Tong, Women ‘s Health Department, Xicheng District Maternal and Child Health Care Hospital, Building 19, Pingyuanli Community, Baizhifang Street, Xicheng District, Beijing, 100054, People’s Republic of China, Email [email protected]; [email protected]: This study aimed to analyze the distribution and factors influencing anti-Müllerian hormone (AMH) levels among family-planning women of childbearing age in Beijing, China.Patients and Methods: We collected the data of 3,236 family-planning women of childbearing age who underwent pre-pregnancy examinations at Xicheng District Maternal and Child Health Hospital in Beijing between October 2021 and July 2024. Collected data included age, education level, ethnicity, height, weight, and systolic and diastolic blood pressure. We calculated the body mass index (BMI) of each participant. The collected blood test results included AMH, fasting blood glucose (FBG), thyroid-stimulating hormone (TSH), creatinine (Cr), and alanine aminotransferase, and hemoglobin levels and platelet count. A structured questionnaire was used to document the subjects’ dietary and lifestyle habits, environmental factors, and emotional and mental stress statuses. The patients were divided into age groups (≥ 36 years versus ≤ 35 years) and factors compared between them. Two different factors influencing AMH level were analyzed using a logistics model.Results: The AMH level decreased with age, with a median AMH of < 2.0 ng/mL for subjects aged ≥ 36 years. Significant intergroup differences were noted in ethnicity, education level, FBG, creatinine level, BMI, diastolic blood pressure, hemoglobin level, smoking rate, and life-related stress level. A logistic regression analysis suggested that age was a negative factor affecting AMH level in both groups (P=0.000 and 0.002, respectively). Hemoglobin and educational levels were also important influential factors of AMH in patients aged ≤ 35 years but not in those aged ≥ 36 years.Conclusion: AMH levels gradually decreased with age. Although nutritional status and educational level significantly impacted AMH levels among women ≤ 35 years of age, their effects decreased thereafter. Thus, 35 years of age is considered an important reproductive boundary for women of childbearing age.Keywords: AMH, women of childbearing age, cross-sectional study

Keywords

• amh
• women of childbearing age
• cross-sectional study