Association of inherited variation within the genes encoding Toll-like rёeceptors with disorders of carbohydrate metabolism among patients with coronary artery disease

Abstract

Aim of the study. To determine the impact of polymorphisms within the genes encoding Toll-like receptors on the development of carbohydrate metabolism disorders (CMDs) amongst patients with coronary artery disease (CAD). Materials and Methods. We recruited 292 patients with CAD and investigated 8 polymorphisms within 4 genes, namely TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), and TLR6 (rs3775073 and rs5743810). Results. Carriers of G allele of rs5743611 polymorphism within TLR1 gene had an increased risk of CMDs. Moreover, the risk of CMDs was 3-fold higher in carriers of G/G genotype of rs5743611 polymorphism between 50 and 70 years of age. However, carriers of Т allele of rs4986791 (Thr399Ile) polymorphism and G allele of rs4986790 (Asp299Gly) polymorphism within TLR4 gene had decreased risk of CMDs. In addition, A/A genotype of rs5743810 polymorphism within TLR6 gene was associated with reduced risk of CMDs in males. Conclusion. There are certain associations of polymorphisms within genes encoding Toll-like receptors and development of CMDs amongst patients with CAD.

Keywords

• ischemic heart disease
• type 2 diabetes mellitus
• atherosclerosis
• toll-like receptors
• gene polymorphisms