Neuroprotective Potential of <i>Guiera senegalensis</i> (Combretaceae) Leaf Hydroethanolic Extract against Cholinergic System Dysfunctions and Oxidative Stress in Scopolamine-Induced Cognitive Impairment in Zebrafish (<i>Danio rerio</i>)
Jorelle Linda Kamda Damo,
Razvan Stefan Boiangiu,
Ion Brinza,
Léa Blondelle Kenko Djoumessi,
Roland Nhouma Rebe,
Balbine Nkwingwa Kamleu,
Simon Désiré Nyayi Guedang,
Guillaume Woumitna Camdi,
Parfait Bouvourné,
Eglantine Wado Keugong,
Hervé Hervé Abaïssou Ngatanko,
Oana Cioanca,
Monica Hancianu,
Harquin Simplice Foyet,
Lucian Hritcu
Affiliations
Jorelle Linda Kamda Damo
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Razvan Stefan Boiangiu
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Ion Brinza
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Léa Blondelle Kenko Djoumessi
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Roland Nhouma Rebe
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Balbine Nkwingwa Kamleu
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Simon Désiré Nyayi Guedang
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Guillaume Woumitna Camdi
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Parfait Bouvourné
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Eglantine Wado Keugong
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Hervé Hervé Abaïssou Ngatanko
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Oana Cioanca
Department of Pharmacognosy, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Monica Hancianu
Department of Pharmacognosy, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Harquin Simplice Foyet
Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
Lucian Hritcu
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Guiera senegalensis JF Gmel. (Combretaceae) (GS) is a plant used in traditional medicine in West Africa for the treatment of several diseases, such as epilepsy and depression. However, its potential benefits in improving scopolamine (Sco)-induced memory impairment and brain oxidative stress in zebrafish have been investigated. In the present study, zebrafish (Danio rerio) were treated with GS (1, 4, and 8 μg/L) for 19 days as well as Sco (100 µM) 30 min before behavioral tests. Behavioral performance was assessed by the Y-maze test and novel object recognition test (NOR), whereas anxiety response was evaluated in the novel tank diving test (NTT). Subsequently, high-performance liquid chromatography (HPLC) was used to evaluate the GS chemical composition. Sco promoted oxidative stress and acetylcholinesterase (AChE) activity. Moreover, both oxidative stress parameters and AChE activity were ameliorated by GS treatment. Accordingly, the present findings further provided the potential use of GS as a natural, alternative treatment against cognitive disorders associated to Alzheimer’s disease (AD).
