Aripiprazole combination for reversal of paliperidone-induced increase in prolactin level

Abstract

Pu Zhi,1,* Yanqiong Wang,1,* Wei Quan,1,2 Yanli Su,1 Hui Zhang1 1Department of Psychiatry, Xi’an Mental Health Center, Institute of Mental Health, Xi’an Medical University, Xi’an, China; 2Department of Natural Medicine, Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an, China *These authors contributed equally to this work Abstract: Hyperprolactinemia is a common side effect of antipsychotic drugs. Although changes of antipsychotic drugs or reduction of their doses can solve this problem, a modification of the treatment regimen can lead to instability in patients. Herein, we followed up a patient with elevated prolactin caused by paliperidone and found that the prolactin level was decreased after the administration of a combination with a low-dose aripiprazole. In addition, we summarized and analyzed the findings from the case and the literature review conducted. Keywords: aripiprazole, schizophrenia, prolactin

Keywords

• aripiprazole
• schizophrenia
• prolactin