Skin parasite landscape determines host infectiousness in visceral leishmaniasis

Johannes S. P. Doehl; Zoe Bright; Shoumit Dey; Helen Davies; John Magson; Najmeeyah Brown; Audrey Romano; Jane E. Dalton; Ana I. Pinto; Jon W. Pitchford; Paul M. Kaye

doi:10.1038/s41467-017-00103-8

Nature Communications (Jul 2017)

Skin parasite landscape determines host infectiousness in visceral leishmaniasis

Johannes S. P. Doehl,
Zoe Bright,
Shoumit Dey,
Helen Davies,
John Magson,
Najmeeyah Brown,
Audrey Romano,
Jane E. Dalton,
Ana I. Pinto,
Jon W. Pitchford,
Paul M. Kaye

Affiliations

Johannes S. P. Doehl: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Zoe Bright: Departments of Biology and Mathematics, University of York
Shoumit Dey: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Helen Davies: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
John Magson: Fera Science Ltd (Fera), Applied Innovation Campus
Najmeeyah Brown: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Audrey Romano: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Jane E. Dalton: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Ana I. Pinto: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
Jon W. Pitchford: Departments of Biology and Mathematics, University of York
Paul M. Kaye: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York

DOI: https://doi.org/10.1038/s41467-017-00103-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Parasitemia has been considered the main determinant of visceral leishmaniasis transmission. By combining imaging, qPCR and experimental xenodiagnoses with mathematical models, Doehl et al. argue that the patchy landscape of parasites in the skin is necessary to explain infectiousness.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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