Biomedical Journal (Dec 2013)

Impact of chronic obstructive pulmonary disease on patient with acute myocardial infarction undergoing primary percutaneous coronary intervention

  • Pei-Hsun Sung,
  • Sheng-Ying Chung,
  • Cheuk-Kwan Sun,
  • Cheng-Hsu Yang,
  • Shyh-Ming Chen,
  • Chi-Ling Hang,
  • Chien-Jen Chen,
  • Kuo-Ho Yeh,
  • Yung-Lung Chen,
  • Chiung-Jen Wu,
  • Hsuen-wen Chang,
  • Tzu-Hsien Tsai,
  • Hon-Kan Yip

DOI
https://doi.org/10.4103/2319-4170.113373
Journal volume & issue
Vol. 36, no. 6
pp. 274 – 281

Abstract

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Background: This study reported the incidence and prognostic outcome of chronic obstructive lung disease (COPD) patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: Between January 2002 and May 2011, totally 1554 consecutive patients who experienced STEMI undergoing primary PCI were enrolled into the study. Results: Of the 1554 patients, 124 (9.7%) with diagnosis of COPD and 1430 (90.3%) without COPD were categorized into group 1 and group 2. Although no difference in in-hospital mortality was noted between the two groups (p = 0.726). However, the hospitalization duration was notably longer (p = 0.003), the incidences of recurrent MI and re-hospitalization for congestive heart failure were significantly higher in group 1 than in group 2 (all p < 0.02). Although Kaplan-Meier analysis demonstrated that the incidence of freedom from one-year major adverse clinical outcome (MACO) (defined as recurrent MI, re-admission for congestive heart failure was significantly lower in group 1 than group 2 (p = 0.012), multivariate Cox regression analysis showed COPD was not an independent predictor of MACO-free time after adjusting traditional risk factors. Conclusion: COPD was not an independent predictor of short-term and medium-term MACO in patients with STEMI undergoing primary PCI.

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