Communications Biology (May 2022)
Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
- Yuxing Xia,
- Stefan Prokop,
- Brach M. Bell,
- Kimberly-Marie M. Gorion,
- Cara L. Croft,
- Lith Nasif,
- Guilian Xu,
- Cara J. Riffe,
- Alyssa N. Manaois,
- Kevin H. Strang,
- Stephan S. Quintin,
- Giavanna Paterno,
- Malú Gámez Tansey,
- David R. Borchelt,
- Todd E. Golde,
- Benoit I. Giasson
Affiliations
- Yuxing Xia
- Department of Neuroscience, College of Medicine, University of Florida
- Stefan Prokop
- Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida
- Brach M. Bell
- Department of Neuroscience, College of Medicine, University of Florida
- Kimberly-Marie M. Gorion
- Department of Neuroscience, College of Medicine, University of Florida
- Cara L. Croft
- Department of Neuroscience, College of Medicine, University of Florida
- Lith Nasif
- Department of Neuroscience, College of Medicine, University of Florida
- Guilian Xu
- Department of Neuroscience, College of Medicine, University of Florida
- Cara J. Riffe
- Department of Neuroscience, College of Medicine, University of Florida
- Alyssa N. Manaois
- Department of Neuroscience, College of Medicine, University of Florida
- Kevin H. Strang
- Department of Neuroscience, College of Medicine, University of Florida
- Stephan S. Quintin
- Department of Neuroscience, College of Medicine, University of Florida
- Giavanna Paterno
- Department of Neuroscience, College of Medicine, University of Florida
- Malú Gámez Tansey
- Department of Neuroscience, College of Medicine, University of Florida
- David R. Borchelt
- Department of Neuroscience, College of Medicine, University of Florida
- Todd E. Golde
- Department of Neuroscience, College of Medicine, University of Florida
- Benoit I. Giasson
- Department of Neuroscience, College of Medicine, University of Florida
- DOI
- https://doi.org/10.1038/s42003-022-03373-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 18
Abstract
A mouse model with a predictable pathogenic tau protein progression is presented, enabling further investigation into tau pathology in neurodegenerative diseases.
