Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Apr 2020)
Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study
- Rui Du,
- Ruizhi Zheng,
- Yu Xu,
- Yuanyue Zhu,
- Xuefeng Yu,
- Mian Li,
- Xulei Tang,
- Ruying Hu,
- Qing Su,
- Tiange Wang,
- Zhiyun Zhao,
- Min Xu,
- Yuhong Chen,
- Lixin Shi,
- Qin Wan,
- Gang Chen,
- Meng Dai,
- Di Zhang,
- Zhengnan Gao,
- Guixia Wang,
- Feixia Shen,
- Zuojie Luo,
- Yingfen Qin,
- Li Chen,
- Yanan Huo,
- Qiang Li,
- Zhen Ye,
- Yinfei Zhang,
- Chao Liu,
- Youmin Wang,
- Shengli Wu,
- Tao Yang,
- Huacong Deng,
- Lulu Chen,
- Jiajun Zhao,
- Yiming Mu,
- Donghui Li,
- Guijun Qin,
- Weiqing Wang,
- Guang Ning,
- Li Yan,
- Yufang Bi,
- Jieli Lu
Affiliations
- Rui Du
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Ruizhi Zheng
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Yu Xu
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Yuanyue Zhu
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Xuefeng Yu
- Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China
- Mian Li
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Xulei Tang
- The First Hospital of Lanzhou University Lanzhou China
- Ruying Hu
- Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China
- Qing Su
- Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China
- Tiange Wang
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Zhiyun Zhao
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Min Xu
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Yuhong Chen
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Lixin Shi
- Affiliated Hospital of Guiyang Medical College Guiyang China
- Qin Wan
- The Affiliated Hospital of Luzhou Medical College Luzhou China
- Gang Chen
- Fujian Provincial Hospital Fujian Medical University Fuzhou China
- Meng Dai
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Di Zhang
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Zhengnan Gao
- Dalian Municipal Central Hospital Dalian China
- Guixia Wang
- The First Hospital of Jilin University Changchun China
- Feixia Shen
- The First Affiliated Hospital of Wenzhou Medical University Wenzhou China
- Zuojie Luo
- The First Affiliated Hospital of Guangxi Medical University Nanning China
- Yingfen Qin
- The First Affiliated Hospital of Guangxi Medical University Nanning China
- Li Chen
- Qilu Hospital of Shandong University Jinan China
- Yanan Huo
- Jiangxi Provincial People’s Hospital Affiliated to Nanchang University Nanchang China
- Qiang Li
- The Second Affiliated Hospital of Harbin Medical University Harbin China
- Zhen Ye
- Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China
- Yinfei Zhang
- Central Hospital of Shanghai Jiading District Shanghai China
- Chao Liu
- Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing China
- Youmin Wang
- The First Affiliated Hospital of Anhui Medical University Hefei China
- Shengli Wu
- Karamay Municipal People’s Hospital Xinjiang China
- Tao Yang
- The First Affiliated Hospital of Nanjing Medical University Nanjing China
- Huacong Deng
- The First Affiliated Hospital of Chongqing Medical University Chongqing China
- Lulu Chen
- Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China
- Jiajun Zhao
- Shandong Provincial Hospital affiliated to Shandong University Jinan China
- Yiming Mu
- Chinese People’s Liberation Army General Hospital Beijing China
- Donghui Li
- Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX
- Guijun Qin
- The First Affiliated Hospital of Zhengzhou University Zhengzhou China
- Weiqing Wang
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Guang Ning
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Li Yan
- Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China
- Yufang Bi
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- Jieli Lu
- State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China
- DOI
- https://doi.org/10.1161/JAHA.119.014175
- Journal volume & issue
-
Vol. 9,
no. 7
Abstract
Background Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community‐dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable‐adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20–1.52), 1.59 (1.08–2.35), 1.40 (1.11–1.78), and 1.44 (1.26–1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40–1.81), 2.20 (1.52–3.20), 1.82 (1.45–2.28), and 1.80 (1.56–2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27–1.81), 2.07 (1.28–3.35), 1.92 (1.42–2.58), and 1.83 (1.50–2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early‐life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area.
Keywords