Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang; Jinpeng Jia; Jimin P. Kim; Fei Yang; Xing Wang; Hong Shen; Sijia Xu; Jian Yang; Decheng Wu

doi:10.1016/j.bioactmat.2017.06.003

Bioactive Materials (Mar 2018)

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang,
Jinpeng Jia,
Jimin P. Kim,
Fei Yang,
Xing Wang,
Hong Shen,
Sijia Xu,
Jian Yang,
Decheng Wu

Affiliations

Jian Zhang: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Jinpeng Jia: Department of Orthopaedics, General Hospital of Chinese People's Liberation Army, Beijing, China
Jimin P. Kim: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
Fei Yang: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Xing Wang: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Hong Shen: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Sijia Xu: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Jian Yang: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
Decheng Wu: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

DOI: https://doi.org/10.1016/j.bioactmat.2017.06.003
Journal volume & issue: Vol. 3, no. 1
pp. 87 – 96

Abstract

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We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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