Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis

Abstract

Ferroptosis is a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors.

Keywords

• ferroptosis
• hippo pathway
• transcriptional coactivator with pdz-binding motif (taz)
• yes-associated protein 1 (yap1)
• nadph oxidase 4 (nox4)
• renal cell carcinoma
• ovarian cancer
• erastin
• epithelial membrane protein 1 (emp1)
• angiopoietin-like 4 (angptl4)
• nadph oxidase 2 (nox2)