Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage

Abstract

Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2ZYG11A/B ubiquitin ligase promotes mitotic slippage. The combination of antimicrotubule drugs and a CRL2ZYG11A/B inhibitor prevents mitotic slippage to increase antimitotic efficacy.

Keywords

• apc/c
• antimicrotubule drugs
• antimitotic chemotherapy
• cullin-ring ubiquitin ligase
• cyclin b1
• mitotic slippage
• tetraploid checkpoint
• tetraploidy
• zyg11a
• zyg11b