Nature Communications (Nov 2017)
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
- Hiro Sato,
- Atsuko Niimi,
- Takaaki Yasuhara,
- Tiara Bunga Mayang Permata,
- Yoshihiko Hagiwara,
- Mayu Isono,
- Endang Nuryadi,
- Ryota Sekine,
- Takahiro Oike,
- Sangeeta Kakoti,
- Yuya Yoshimoto,
- Kathryn D. Held,
- Yoshiyuki Suzuki,
- Koji Kono,
- Kiyoshi Miyagawa,
- Takashi Nakano,
- Atsushi Shibata
Affiliations
- Hiro Sato
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Atsuko Niimi
- Research Program for Heavy Ion Therapy, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR)
- Takaaki Yasuhara
- Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Tiara Bunga Mayang Permata
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Yoshihiko Hagiwara
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Mayu Isono
- Advanced Scientific Research Leaders Development Unit, Gunma University
- Endang Nuryadi
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Ryota Sekine
- Advanced Scientific Research Leaders Development Unit, Gunma University
- Takahiro Oike
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Sangeeta Kakoti
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Yuya Yoshimoto
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Kathryn D. Held
- Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School
- Yoshiyuki Suzuki
- Department of Radiation Oncology, Fukushima Medical University
- Koji Kono
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
- Kiyoshi Miyagawa
- Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Takashi Nakano
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
- Atsushi Shibata
- Advanced Scientific Research Leaders Development Unit, Gunma University
- DOI
- https://doi.org/10.1038/s41467-017-01883-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling.
