STIMULATION OF REPARATIVE REGENERATION OF SUPPORTING TISSUE UNDER CONDITIONS OF DELAYED APPOSITION OF FRAGMENTS

Abstract

The study is devoted to reparative regeneration of supporting tissue in the area of the defect using the methods of acupuncture with stimulation of biological active points when modeling delayed apposition of fragments. Material and methods. The work was performed using laboratory animals of the Chinchilla rabbits, at the age of 6 months. The delayed apposition of shin bone fragments was simulated in all animals. In the dynamics of the study, an assessment of radiological and morphological changes in the area of the bone defect was performed. After the fragments were compared and fixed using animal randomization methods, the animals were divided into two groups – the control and the main group, in which the biologically active points were stimulated. Results and discussion. The evaluation of the supporting tissue regeneration in the defect zone under the influence of proposed biologically active points combination by the method of acupuncture within the conditions of delayed apposition of shin bone fragments has revealed physiological change of regeneration phases with the formation of differentiated bone tissue and bone marrow elements to the 50th day of the study. The 2 fold predominance of bone tissue, 2 fold — the bone marrow substance, a decrease in cartilage tissue, the absence of fibrous connective tissue have been revealed compared with the control group, where the slowdown in the physiological change of regeneration phases and the formation of regenerate supporting tissue in the form of pseudarthrosis have been revealed.

Keywords

• regeneration
• pseudarthrosis
• shin
• bone morphometry
• biologically active points