Lupus anticoagulant in children – a confounding factor in diagnosis and targeted therapy

Abstract

Introduction: Lupus anticoagulant (LAC) belongs to a heterogeneous group of antibodies directed against negatively charged phospholipid-binding proteins, inhibiting phospholipid-dependent reactions. We assessed the frequency, etiological background, clinical and biological expression as well as the appropriate management and outcome of LAC in a pediatric population.

Keywords

• antiphospholipid syndrome
• acquired hemophilia
• activated partial thromboplastin time
• lupus anticoagulant