NRF2 in Viral Infection

Angela Herengt; Jacob Thyrsted; Christian K. Holm

doi:10.3390/antiox10091491

Antioxidants (Sep 2021)

NRF2 in Viral Infection

Angela Herengt,
Jacob Thyrsted,
Christian K. Holm

Affiliations

Angela Herengt: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
Jacob Thyrsted: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
Christian K. Holm: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark

DOI: https://doi.org/10.3390/antiox10091491
Journal volume & issue: Vol. 10, no. 9
p. 1491

Abstract

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The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.

Published in Antioxidants

ISSN: 2076-3921 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.mdpi.com/journal/antioxidants

About the journal

Abstract

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