Research advance of mitochondrial dysfunction in the mechanism of renal stone formation

Abstract

The relationship among oxidative stress, inflammations and stone formation has been proved. Mitochondria, as one of the most important organelles in cell, plays an important role in energy supply, oxidative stress, calcium homeostasis and cell programmed death. Mitochondrial dysfunction may accelerate the kidney stone-forming, which may be related to the decreased antioxidant capacity, the activation of inflammatory pathways, the imbalance of intracellular calcium and oxalic acid homeostasis. To clarify the roles of mitochondrial dysfunction in the formation of kidney stones may support the research on pathogenesis of the disease and to provide some potential novel ideas in the prophylactic study of renal stone in future.

Keywords

• oxidative stress|calcium homeostasis|mitochondria|renal stone|stone formation