Nature Communications (Dec 2022)
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
- Ryan G. Lim,
- Osama Al-Dalahmah,
- Jie Wu,
- Maxwell P. Gold,
- Jack C. Reidling,
- Guomei Tang,
- Miriam Adam,
- David K. Dansu,
- Hye-Jin Park,
- Patrizia Casaccia,
- Ricardo Miramontes,
- Andrea M. Reyes-Ortiz,
- Alice Lau,
- Richard A. Hickman,
- Fatima Khan,
- Fahad Paryani,
- Alice Tang,
- Kenneth Ofori,
- Emily Miyoshi,
- Neethu Michael,
- Nicolette McClure,
- Xena E. Flowers,
- Jean Paul Vonsattel,
- Shawn Davidson,
- Vilas Menon,
- Vivek Swarup,
- Ernest Fraenkel,
- James E. Goldman,
- Leslie M. Thompson
Affiliations
- Ryan G. Lim
- UCI MIND, University of California Irvine
- Osama Al-Dalahmah
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Jie Wu
- Department of Biological Chemistry, University of California Irvine
- Maxwell P. Gold
- Department of Biological Engineering, Massachusetts Institute of Technology
- Jack C. Reidling
- UCI MIND, University of California Irvine
- Guomei Tang
- Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Miriam Adam
- Department of Biological Engineering, Massachusetts Institute of Technology
- David K. Dansu
- Advanced Science Research Center at the City University of New York
- Hye-Jin Park
- Advanced Science Research Center at the City University of New York
- Patrizia Casaccia
- Advanced Science Research Center at the City University of New York
- Ricardo Miramontes
- UCI MIND, University of California Irvine
- Andrea M. Reyes-Ortiz
- Department of Biological Chemistry, University of California Irvine
- Alice Lau
- Department of Psychiatry and Human Behavior, University of California Irvine
- Richard A. Hickman
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Fatima Khan
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Fahad Paryani
- Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Alice Tang
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Kenneth Ofori
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Emily Miyoshi
- Department of Neurobiology and Behavior, University of California Irvine
- Neethu Michael
- Department of Pathology, University of California Irvine
- Nicolette McClure
- Department of Neurobiology and Behavior, University of California Irvine
- Xena E. Flowers
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Jean Paul Vonsattel
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Shawn Davidson
- Lewis-Sigler Institute for Integrative Genomics
- Vilas Menon
- Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Vivek Swarup
- UCI MIND, University of California Irvine
- Ernest Fraenkel
- Department of Biological Engineering, Massachusetts Institute of Technology
- James E. Goldman
- Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Leslie M. Thompson
- UCI MIND, University of California Irvine
- DOI
- https://doi.org/10.1038/s41467-022-35388-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
Here the authors evaluate single cell gene expression from mouse and human Huntington’s disease brains, finding incomplete oligodendrocyte maturation and pathways involved. Treating mice with thiamine/biotin ameliorates molecular pathology.
