Highly Heterogeneous Excitatory Connections Require Less Amount of Noise to Sustain Firing Activities in Cortical Networks

Abstract

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Cortical networks both in vivo and in vitro sustain asynchronous irregular firings with extremely low frequency. To realize such self-sustained activity in neural network models, balance between excitatory and inhibitory activities is known to be one of the keys. In addition, recent theoretical studies have revealed that another feature commonly observed in cortical networks, i.e., sparse but strong connections and dense weak connections, plays an essential role. The previous studies, however, have not thoroughly considered the cooperative dynamics between a network of such heterogeneous synaptic connections and intrinsic noise. The noise stimuli, representing inherent nature of the neuronal activities, e.g., variability of presynaptic discharges, should be also of significant importance for sustaining the irregular firings in cortical networks. Here, we numerically demonstrate that highly heterogeneous distribution, typically a lognormal type, of excitatory-to-excitatory connections, reduces the amount of noise required to sustain the network firing activities. In the sense that noise consumes an energy resource, the heterogeneous network receiving less amount of noise stimuli is considered to realize an efficient dynamics in cortex. A noise-driven network of bi-modally distributed synapses further shows that many weak and a few very strong synapses are the key feature of the synaptic heterogeneity, supporting the network firing activity.

Keywords

• network firing activity
• cortical network
• lognormal distribution
• excitatory and inhibitory connections
• heterogeneity
• synaptic noise