Comparison of Lipid Profile between People with Oral Lichen Planus and Healthy People

Abstract

Introduction: Lichen planus is a relatively common chronic inflammatory mucocutaneous disease with unknown etiology and pathogenesis. Dyslipidemia caused by chronic inflammation results in the formation of atherosclerotic plaques which is associated with the risk of cardiovascular diseases. There is a dearth of studies with conflicting results in this regard; therefore, the present study aimed to compare the lipid profile as a risk factor for cardiovascular disease between patients with oral lichen planus and healthy people.Materials and Methods: This case-control study was conducted in 2019. Firstly, the aim of the study was explained to the patients and written consent was obtained. Thereafter, the patients' blood pressure and body mass index (BMI) were recorded in the data collection form. The patients were referred to the laboratory to check their cholesterol (HDL, LDL) and triglyceride levels. Data were analyzed in SPSS software (version 18) using the Mann-Whitney U test to analyze the data and compare the indicators in the two groups.Results: The mean age scores of the participants were obtained at 46.7±16.9 and 41.5±10.1 years in the Liken Plan oral and control groups, respectively, and they did not differ significantly (P=0.59). There was a statistically significant difference between the two groups in terms of LDL and HDL, and the rates of LDL and HDL were higher in healthy people and OLP patients (P=0.036 and P=0.04, respectively); nonetheless, they were in the normal range in both groups.Conclusion: Dyslipidemia was normal in patients with OLP, and oral lichen planus did not appear to be a single risk factor for dyslipidemia.