Case Reports in Urology (Jan 2020)

KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature

  • Sarah Bouri,
  • Jean-Christophe Noël,
  • Xavier Catteau,
  • Walid Al Hajj Obeid,
  • Ilyas Svistakov,
  • Thierry Roumeguère,
  • Nicky D’Haene,
  • Sandrine Rorive

DOI
https://doi.org/10.1155/2020/5419707
Journal volume & issue
Vol. 2020

Abstract

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Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.