CLINICAL SIGNIFICANCE OF SERUM AND URINARY HEAT SHOCK PROTEIN 70 LEVEL ASSESSMENT IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS

Abstract

The levels of urinary heat shock protein-70 and serum antibodies to the heat shock protein-70 were assessed in 79 patients with different course variants of the chronic glomerulonephritis. The indices studied were higher in patients with an active course of the disease (expressed urinary and nephritic syndromes, especially if associated with transient renal disturbances which reflected the degree of lesion and activation of the renal self-defence system. Decrease of the serum level of antibodies to the heat shock protein-70 was an unfavorable factor of the nephrotic syndrome persistence despite the immunosuppressive therapy.

Keywords

• хронический гломерулонефрит
• chronic glomerulonephritis
• нефротический синдром
• nephrotic syndrome
• самозащита почки
• kidney self-defense
• белок теплового шока-70
• антитела к белку теплового шока-70
• экскреция белка теплового шока-70 с мочой
• heat shock protein 70 urinary excretion
• heat shock protein 70
• heat shock protein 70 antibody