Nature Communications (Oct 2016)
Disposal of iron by a mutant form of lipocalin 2
- Jonathan Barasch,
- Maria Hollmen,
- Rong Deng,
- Eldad A. Hod,
- Peter B. Rupert,
- Rebecca J. Abergel,
- Benjamin E. Allred,
- Katherine Xu,
- Shaun F. Darrah,
- Yared Tekabe,
- Alan Perlstein,
- Rebecca Wax,
- Efrat Bruck,
- Jacob Stauber,
- Kaitlyn A. Corbin,
- Charles Buchen,
- Vesna Slavkovich,
- Joseph Graziano,
- Steven L. Spitalnik,
- Guanhu Bao,
- Roland K. Strong,
- Andong Qiu
Affiliations
- Jonathan Barasch
- Columbia University, Russ Berrie Medical Science Pavilion
- Maria Hollmen
- Columbia University, Russ Berrie Medical Science Pavilion
- Rong Deng
- Columbia University, Russ Berrie Medical Science Pavilion
- Eldad A. Hod
- Columbia University, Russ Berrie Medical Science Pavilion
- Peter B. Rupert
- Basic Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine Biochemistry, Immunology
- Rebecca J. Abergel
- Chemical Sciences Division, Lawrence Berkeley National Laboratory, BioActinide Chemistry Group
- Benjamin E. Allred
- Chemical Sciences Division, Lawrence Berkeley National Laboratory, BioActinide Chemistry Group
- Katherine Xu
- Columbia University, Russ Berrie Medical Science Pavilion
- Shaun F. Darrah
- Columbia University, Russ Berrie Medical Science Pavilion
- Yared Tekabe
- Columbia University, Russ Berrie Medical Science Pavilion
- Alan Perlstein
- Columbia University, Russ Berrie Medical Science Pavilion
- Rebecca Wax
- Columbia University, Russ Berrie Medical Science Pavilion
- Efrat Bruck
- Columbia University, Russ Berrie Medical Science Pavilion
- Jacob Stauber
- Columbia University, Russ Berrie Medical Science Pavilion
- Kaitlyn A. Corbin
- Columbia University, Russ Berrie Medical Science Pavilion
- Charles Buchen
- Columbia University, Russ Berrie Medical Science Pavilion
- Vesna Slavkovich
- Columbia University, Russ Berrie Medical Science Pavilion
- Joseph Graziano
- Columbia University, Russ Berrie Medical Science Pavilion
- Steven L. Spitalnik
- Columbia University, Russ Berrie Medical Science Pavilion
- Guanhu Bao
- State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences, Anhui Agricultural University
- Roland K. Strong
- Basic Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine Biochemistry, Immunology
- Andong Qiu
- Columbia University, Russ Berrie Medical Science Pavilion
- DOI
- https://doi.org/10.1038/ncomms12973
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mouse models.
