In this paper, we investigate a blow-up criterion for compressible magnetohydrodynamic equations. It is shown that if density and velocity satisfy (∥ρ∥L∞(0,T;L∞)+∥u∥C([0,T];L3)∞), then the strong solutions to isentropic magnetohydrodynamic equations can exist globally over [0,T]. Notably, our analysis accommodates the presence of an initial vacuum.