Acute Drug-Induced Cholestatic Syndrome in Basedow Graves’ Disease

Abstract

Introduction: Graves’ disease (GD), an autoimmune disorder caused by high levels of auto-antibodies against the thyroid-stimulating hormone receptor, is considered the most common cause of thyrotoxicosis, characterized by features such as goiter, ophthalmopathy and dermopathy. In our country, the administration of antithyroid drugs (ATD) is the first line of treatment in this disease. Side effects are rare but some of them, such as agranulocytosis or liver damage, may become serious.

Keywords

• graves’ disease
• methimazole
• hepatitis
• cytolysis
• cholestatic syndrome