Neuropsychiatric Disease and Treatment (Aug 2022)
The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
Abstract
Zongbo Zhao,* Jianzhong Xue,* Ziliang Zhuo, Wei Zhong, Hui Liu Department of Neurology and Institute of Neurology, The Affiliated Changshu Hospital of Xuzhou Medical University, Suchow, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Liu, Tel/Fax +860512-52925530, Email [email protected]: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people.Methods: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.Results: With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p< 0.001, OR=3.61 (95% CI 2.25– 5.83); recessive model (adjusted): p< 0.001, OR=6.80 (95% CI 3.49– 13.89)].Conclusion: Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.Keywords: single-nucleotide polymorphism, multiple sclerosis, IL7R, interleukin
