Kinetics, mechanistic and synergistic studies of Alpha lipoic acid with hydrogen peroxide

Abstract

Alpha lipoic acid (ALA) holds redox behavior that was observed in the presence of different metals utilizing hydrogen peroxide (H2O2) as a strong oxidizing agent. The effects of different parameters like temperature, pH and concentrations were also monitored. ALA in the presence of hydrogen peroxide (H2O2) showed oxidation as well as degradation processes. To monitor the oxidation kinetics of ALA in the presence of different essential metals to find its reaction pathway using salt affect parameters. The redox behavior of Alpha lipoic acid (ALA) was found to be significant at pH ranging from 4 to 10, at 29 °C in a given pseudo first order reaction conditions. The values of the rate constant in the presence of different essential metals such as Mo, Se, Co, Cr, Fe, and Zn were also obtained. Furthermore, synergistic effects were observed in the presence of Mo6+ and Fe2+ at all applied conditions. Activation energy of ALA oxidation is 36.7 kJ whereas in the presence of Fe2+ its activation energy went up to 48 kJ; however, in the presence of Mo6+ the activation energy drops to 18.3 kJ. In the presence of Fe2+ and Mo6+ the synergistic effect works and its activation energy became 36.5 kJ. The reaction mechanism was also proposed.

Keywords

• Alpha lipoic acid
• Hydrogen peroxide
• Synergism
• Oxidation
• Reaction mechanism