Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis

Keke Qi; Liutian Wu; Chengyuan Liu; Yang Pan

doi:10.3390/metabo11110780

Metabolites (Nov 2021)

Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis

Keke Qi,
Liutian Wu,
Chengyuan Liu,
Yang Pan

Affiliations

Keke Qi: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Liutian Wu: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Chengyuan Liu: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Yang Pan: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China

DOI: https://doi.org/10.3390/metabo11110780
Journal volume & issue: Vol. 11, no. 11
p. 780

Abstract

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Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a large number of compounds in biological tissue sections in ambient conditions. In this review, the developments of various AMSI techniques are discussed according to one-step and two-step ionization strategies. In addition, recent applications of AMSI for lipid and metabolite analysis (from 2016 to 2021) in disease diagnosis, animal model research, plant science, drug metabolism and toxicology research, etc., are summarized. Finally, further perspectives of AMSI in spatial resolution, sensitivity, quantitative ability, convenience and software development are proposed.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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