Neuropsychiatric Disease and Treatment (Nov 2023)
Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
Abstract
Huanxi Liu,1,2 Ligang Wang,2 Hui Yu,2 Jun Chen,3,* Ping Sun2,* 1Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 2Qingdao Mental Health Center, Qingdao, 266034, People’s Republic of China; 3Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Chen, Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email [email protected] Ping Sun, Mental Health Center, Qingdao, 266034, People’s Republic of China, Tel +86 13589394393, Email [email protected]: Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD.Keywords: bipolar disorder, polygenic risk scores, risk forecast
