Biomedicines
(Feb 2022)
Research into Morphofunctional Characteristics of Erythrocytes in COVID-19 Patients
Victor Revin,
Larisa Balykova,
Sergey Pinyaev,
Ilya Syusin,
Olga Radaeva,
Nadezhda Revina,
Yuliya Kostina,
Evgeniy Kozlov,
Vera Inchina,
Igor Nikitin,
Alexandr Salikov,
Ilya Fedorov
Affiliations
Victor Revin
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Larisa Balykova
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Sergey Pinyaev
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Ilya Syusin
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Olga Radaeva
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Nadezhda Revina
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Yuliya Kostina
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Evgeniy Kozlov
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Vera Inchina
Federal State Budgetary Educational Institution of Higher Education, Ogarev Mordovia State University, 430005 Saransk, Russia
Igor Nikitin
Federal State Autonomous Institution, Treatment and Rehabilitation Center of the Ministry of Health of the Russian Federation, 125367 Moscow, Russia
Alexandr Salikov
State Budgetary Institution of Healthcare, City Clinical Hospital after V.M. Buyanov of the Moscow Department of Health, 115516 Moscow, Russia
Ilya Fedorov
State Budgetary Institution of Healthcare, City Clinical Hospital after V.M. Buyanov of the Moscow Department of Health, 115516 Moscow, Russia
DOI
https://doi.org/10.3390/biomedicines10030553
Journal volume & issue
Vol. 10,
no. 3
Abstract
Read online
In this paper, the erythrocytes of healthy donors and people with a confirmed diagnosis of COVID-19 were tested by Raman spectroscopy and laser interference microscopy. We argue that erythrocytes (red blood cells) in COVID-19 patients have an irregular shape, and their morphometric characteristics are impaired in comparison to healthy red blood cells. Raman spectroscopy also allows us to detect a decreased oxygen transport function of these erythrocytes. The combination of these methods—Raman spectroscopy and laser interference microscopy—is a highly effective method for the diagnosis of SARS-CoV-2.
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