Studying the effects of B2B e-commerce adoption on the SMEs process and structure is crucial for businesses. Extant researches have investigated the impacts of adopting e-commerce and provided some findings, but the varied theoretical approaches have produced results that reflect the impacts of either external or internal factors of adopting e-commerce. However, these approaches did not use a complete model with a broader view of the influential factors and since there is an obvious co-relation between these factors, it is essential to further study and examines the factors behind this problem. This paper attempts to provide a complete framework that covers the two types of factors for which the enterprises can use as a reference. The model was developed based on the latest research findings and enriched by some latest countries adoption trial like China and Iran.