Case Reports in Gastroenterology (2017-08-01)

Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid

  • Jenny Sarah Schneider,
  • Matteo Montani,
  • Felix Stickel

Journal volume & issue
Vol. 11, no. 2
pp. 440 – 445


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Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.